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August 3, 2004
U.S. Department of Health and Human Services
NATIONAL INSTITUTES OF HEALTH
NIH News
National Institute of Arthritis and
Musculoskeletal and Skin Diseases
http://www.niams.nih.gov/
FOR IMMEDIATE RELEASE
Tuesday, August 3, 2004
CONTACT:
Kelli Carrington
carringk@mail.nih.gov
NEW STUDY TO SHOW HOW RHEUMATOID ARTHRITIS PATIENTS RATE IMPROVEMENT CHANGE
A new clinical study to determine how people with
rheumatoid arthritis (RA) evaluate improvements in disease symptoms will be carried out by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the Department of Health and Human Services' National Institutes of Health. The study will examine how much of an improvement in pain, stiffness, function and other symptoms is needed before patients consider the change important.
The "Clinically Important Changes in Rheumatoid Arthritis" study will recruit 300 people 18 years of age or older who have been diagnosed with RA. Researchers are particularly interested in patients who are currently being treated with prednisone, methotrexate, leflunomide, infliximab or etanercept.
Patients will be evaluated twice at the NIH Clinical Center
in Bethesda, Md.: once at the start of the study and again
over a 1- to 4-month period. At each visit, patients will undergo assessments, including a physical exam, a grip strength test, a walking test and a blood test. They will complete a computer-based exercise, and answer written questionnaires.
The questionnaires will ask patients to rate the importance
of change in pain, morning stiffness, fatigue, joint
swelling, functioning, worry, depression and overall impressions since the first visit.
Many people with RA complain about the daily joint pain
that is associated with the disease. In addition, doctors
have noted that patients have feelings of helplessness, depression and anxiety. These symptoms together can interfere with a person's ability to carry out normal daily activities.
Generally, doctors evaluate patients' health and treatment based on measures such as the number of joints that are tender or swollen, morning stiffness, grip strength and pain severity. Less attention is given to whether treatment results are meaningful to patients.
The results of this study will give doctors a measure of
the degree of improvements in symptoms and signs of
arthritis that patients think are important. This will
provide a target to be used in evaluating new treatments.
Using these patient-based criteria, doctors will know if a
new treatment has a high likelihood of being rated by
patients as helpful or not.
Rheumatoid arthritis is an autoimmune disease that affects
2.1 million Americans, occurring two to three times more
often in women than in men. RA typically affects many
joints and is a chronic ongoing illness, requiring long
periods of observation and management. It is characterized
by inflammation of the membrane lining the joint, which
causes pain, stiffness, warmth, redness and swelling. The inflamed joint lining, the synovium, can invade and damage bone and cartilage.
For additional information on the RA clinical trial, please
contact:
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: (301) 594-9774 (local), 1-866-411-1010 (toll free)
or e-mail at prpl@cc.nih.gov
The mission of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), a part of the Department of Health and Human Services' National Institutes of Health, is to support research in the causes, treatment and prevention of arthritis and musculoskeletal and skin diseases, the training of basic and clinical scientists to carry out this research and the dissemination of information on research progress in these diseases. For more information about NIAMS, call the information clearinghouse at (301) 495-4484 or (877) 22-NIAMS or visit the NIAMS Web site at http://www.niams.nih.gov.
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