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With prescription drugs Vioxx and Bextra already pulled from the market, a study has raised disturbing questions about the heart safety of long-term use of over-the-counter pain relievers such as Advil, Motrin and Aleve.

Smokers in Norway who took such drugs for at least six months had twice the risk of dying of a heart attack, stroke or other heart-related problem.

The findings came from a study of whether these pain relievers could prevent oral cancer. The drugs did, in fact, cut the risk of developing oral cancer in half, but the deaths that were prevented were offset by the increased risk of dying from cardiovascular disease, according to the study, reported Monday at an American Association for Cancer Research conference in Anaheim.

The study was relatively small - 908 people - and involved people prone to heart problems and cancer because they smoked. But specialists said it supports the U.S. Food and Drug Administration's recent decision to warn about long-term use of all such painkillers except Aspirin.

The findings add to the suspicion that the heart risk extends beyond the so-called cox-2 drugs - Bextra, Vioxx and Celebrex - to the larger family of medications known as non-steroidal anti-inflammatory drugs, or NSAIDs, which include naproxen, ibuprofen and virtually all other over-the-counter pain relievers except acetaminophen or Tylenol.

In recent months, many doctors have switched patients to these over-the-counter medications, believing them to be safer alternatives.

"To the best of our knowledge, these are the first data to support putting a box warning on NSAIDs, not just cox-2s," said Dr. Andrew Dannenberg, a Cornell University scientist who helped do the Norway study.

Vioxx was pulled from the market last fall when a different study, testing whether it could prevent colon cancer, showed a higher heart disease risk. The FDA recently persuaded Pfizer to stop selling Bextra for safety reasons, but Pfizer's Celebrex was allowed to remain. Some researchers from the new study in Norway have been Pfizer consultants.

Some results from the Norway study were presented in February hearings at the FDA, but consisted of only one summary slide and "nobody really picked up on it," said Dr. Raymond DuBois, a Vanderbilt University cancer expert who had no role in the work.

The fresh information presented on Monday should persuade others to study these over-the-counter drugs in more depth, DuBois said.

Oral cancer is a deadly and disfiguring disease that is an especially big problem in Asia. Worldwide, about 275,000 cases and 127,000 deaths occur each year.

Dr. Jon Sudbo of the Norwegian Radium Hospital in Oslo, who led the research, and others wanted to see if NSAIDs could prevent oral cancer, since studies showed they could help ward off other types of cancer. They chose more than 3,000 people at high risk for oral cancer because of their smoking habits from the Norwegian Cancer Registry, a database of more than 123,000 people.

Source: AP